Vakıf Kültür Varlıklarını Koruma Uygulama ve Araştırma Merkezi (KURAM)Vakıf Kültür Varlıklarını Koruma Uygulama ve Araştırma Merkezi (KURAM) tarafından yapılan çalışmaları kapsamaktadır.https://hdl.handle.net/11352/35542024-03-29T13:50:46Z2024-03-29T13:50:46Zİslam Öncesi ve Sonrası ile Ayasofya Camii Geometrik Desenlerinin Mukayeseli AnaliziSönmez, Serap Ekizlerhttps://hdl.handle.net/11352/48102024-03-15T06:39:48Z2024-01-01T00:00:00Zİslam Öncesi ve Sonrası ile Ayasofya Camii Geometrik Desenlerinin Mukayeseli Analizi
Sönmez, Serap Ekizler
Bu çalışmada Ayasofya Camii’nde yer alan geometrik desenlerin pergel-cetvel (çizgilik) konstrüksiyonu ile çizimine ve
arkalarında yatan geometrik sistemlere odaklanılmıştır. Neredeyse tüm İslam coğrafyasında sayısız örnekle ve özellikle 9.
yüzyıldan sonra daha ileri pergel-cetvel konstrüksiyon bilgisi gerektiren tasarımlarla karşımıza çıkan geometrik desenleri
İslam Dönemi’nin âdeta bir kimliği hâline getiren özellikler vardır. Bilim ve sanatın kesişim kümesinde olan geometrik
desenler, genellikle yapısındaki geometri göz ardı edilerek sadece tespitler üzerinden bilimsel çalışmalara yansımaktadır.
Pergel-cetvel konstrüksiyonu ile bir desenin inşası kaynağını Öklid (MÖ 3. yüzyıl) geometrisinden almaktadır.
Bu çalışmada, geleneğe ait olan bu inşa metodu kullanılarak Ayasofya Camii’nde yer alan desenlerin analizleri yapılmış ve
İslam Öncesi Dönem uygulamaları ile sonrasında ortaya konulan desenler mukayese edilmiştir. Ayasofya özelinde yapılan
bu mukayese ile birlikte genel bir İslam öncesi ve sonrası sürecine dair değerlendirmede bulunulmuştur. Desenlerin
analizinde ilk kez bu makale ile literatüre kazandırılan “nizamî” kelimesine açıklık getirilerek doğru bir konstrüksiyon
için önemine değinilmiştir. Bunların neticesinde genel olarak geometrik desenleri tanımlarken kullanılan başlıklarda
“İslam” kelimesinin yer almasının sebepleri masaya yatırılmıştır. İlave olarak cami minberinde yer alan desenlerin yapısı
üzerinden Ayasofya Camii minberinin tarihlendirilmesine dair bir öneride bulunulmuştur. Bu çalışma ile birlikte sanat
tarihi bağlamında ele alınan geometrik desenlerin analiz boyutu ile bilim tarihi, hatta kültür tarihi yazımı için de bir
vesika değeri taşıyıp taşımadığı sorgulanmıştır.
2024-01-01T00:00:00ZEnhancement of Cytotoxic and Apoptotic Activity Through Oolong Tea Extract-mediated CuO/Cu2O NanoparticlesKarakuş, Emir ErselSert, EsraErol, AyşeKalındemirtaş, Ferdane DanışmanÖzbaş, FatihKarakuş, Selcanhttps://hdl.handle.net/11352/48092024-03-15T06:32:06Z2024-01-01T00:00:00ZEnhancement of Cytotoxic and Apoptotic Activity Through Oolong Tea Extract-mediated CuO/Cu2O Nanoparticles
Karakuş, Emir Ersel; Sert, Esra; Erol, Ayşe; Kalındemirtaş, Ferdane Danışman; Özbaş, Fatih; Karakuş, Selcan
The development of multifunctional nanoformulations with enhanced anticancer activity and drug delivery potential is of increasing scientific importance. In this study, we synthesized and characterized copper oxide nanoparticles mediated by oolong tea extract (OE-CuO/Cu2O NPs) using a variety of techniques, including TEM, XRD, FTIR, and UV–Vis spectroscopy, to assess their physical and chemical properties. Remarkably, the results revealed that OE/CuO NPs exhibited significantly enhanced anticancer activity compared to OE alone. The effects of OE and OE-CuO/Cu2O NPs were on cytotoxicity, apoptosis, and cell cycle progression. Furthermore, we assessed the impact of these nanostructures on CD44/24 antibodies, known as aggressive cell markers, following treatment. The green OE-CuO/Cu2O NPs displayed remarkable inhibitory effects on colon cancer HCT116 and breast cancer cells MCF-7 cells. It was shown that OE-CuO/Cu2O NPs reduced the production of the CD44 antibody, provided cell cycle arrest, and encouraged apoptosis. More specifically, it was discovered that these NPs caused MCF-7 cells to undergo apoptosis and G2/M phase cell cycle arrest. Additionally, drug delivery investigations were conducted to evaluate the potential of OE-CuO/Cu2O NPs as drug nanocarriers, further underscoring their promise in developing novel anticancer agents with significant cytotoxic, apoptotic, and drug delivery properties.
2024-01-01T00:00:00ZSustainable Synthesis of Green Cu2O Nanoparticles using Avocado Peel Extract as Biowaste SourceÖzbaş, Fatihhttps://hdl.handle.net/11352/47132024-01-12T14:05:59Z2024-01-01T00:00:00ZSustainable Synthesis of Green Cu2O Nanoparticles using Avocado Peel Extract as Biowaste Source
Özbaş, Fatih
In recent years, there has been a significant shift towards the production of advanced nanomaterials
using sustainable methods, reflecting a heightened focus on reducing environmental impact and optimizing
resource utilization. This growing interest stems from the necessity to address environmental concerns and
embrace eco-friendly practices in material synthesis. The primary objective of this study is to explore the ecofriendly synthesis of novel metal oxide nanoparticles (NPs) by utilizing bio-waste as a sustainable precursor. The
central theme revolves around employing ultrasound-assisted techniques for Cu2O NP synthesis, with a specific
emphasis on utilizing avocado peel waste as an effective phytochemical compound for capping. Through
systematic process optimization, we conducted a comprehensive assessment of the resulting NPs, delving into
their chemical, thermal, and surface properties. Advanced characterization techniques, including X-ray Diffraction
analysis (XRD), Transmission Electron Microscopy (TEM), Thermogravimetric Analysis (TGA), Differential Scanning
Calorimetry (DSC), and Fourier-transform Infrared Spectroscopy (FT-IR), were employed to gain profound insights
into the attributes of the synthesized NPs. Our experimental results conclusively demonstrate the successful
synthesis of spherical Cu2O NPs, each with a diameter of 25 ± 2 nm. This was achieved by utilizing avocado peel
waste (APW) and ultrasound-assisted cavitation at room temperature. The study significantly contributes to our
understanding of the potential applications of green synthesis methods, paving the way for environmentally
friendly and cost-effective Cu2O NPs.
2024-01-01T00:00:00ZA New Natural Secondary Reference Material for Garnet U-Pb Dating by TIMS and LA-ICP-MSAysal, NamıkGuillong, MarcelBayanova, TamaraFukuyama, MayukoLeonard, NicoleYılmaz, İsakVarol, ElifTükel, Fatma ŞişmanKadıoğlu, Yusuf KaanHanilçi, NurullahUzun, FulyaKaygısız, Ersinhttps://hdl.handle.net/11352/45432023-04-28T10:11:08Z2023-01-01T00:00:00ZA New Natural Secondary Reference Material for Garnet U-Pb Dating by TIMS and LA-ICP-MS
Aysal, Namık; Guillong, Marcel; Bayanova, Tamara; Fukuyama, Mayuko; Leonard, Nicole; Yılmaz, İsak; Varol, Elif; Tükel, Fatma Şişman; Kadıoğlu, Yusuf Kaan; Hanilçi, Nurullah; Uzun, Fulya; Kaygısız, Ersin
Gem quality andradite-rich garnet (IUC-1), obtained from the Miocene trachyte dome near Ankara city (Turkey), has been
identified as a potential natural secondary reference material for U-Pb dating. In this study, U-Pb dating was performed in
five different laboratories using isotope dilution TIMS and laser ablation ICP-MS to determine the homogeneity of
euhedral garnet crystals. The U-Pb ID-TIMS data for IUC-1 yielded 207Pb/235U and 206Pb/238U ages of 20.9 0.4 and
20.6 0.8 Ma respectively, and these values are consistent with U-Pb LA-ICP-MS analyses, in which different garnet
crystals yielded ages of 20.8 0.1, 20.7 0.1, 20.7 0.2 and 20.2 0.1 Ma. An andradite (IUC-2) from the
Serc eoren wollastonite skarn (Turkey) can be used as a secondary reference material provided detailed imaging of the €
crystals is undertaken. ID-TIMS data yielded 207Pb/235U and 206Pb/238U ages of 20.4 0.4 and 20.9 1.0 Ma
respectively, and yielded U-Pb ages on different grains of 20.5 0.1, 20.7 1.0, 20.8 1.7 and 20.9 1.6 Ma. The
assigned weighted mean age of IUC-1 (20.4 0.5 Ma, 2s) is proposed as a 2023 reference value. IUC-1 garnet is
expected to contribute significantly to rapidly developing garnet geochronology in the near future.
2023-01-01T00:00:00Z