Show simple item record

dc.contributor.authorÇiftçi, Fatih
dc.contributor.authorÖzarslan, Ali Can
dc.date.accessioned2023-11-24T13:04:24Z
dc.date.available2023-11-24T13:04:24Z
dc.date.issued2023en_US
dc.identifier.citationÇİFTÇİ, Fatih & Ali Can ÖZARSLAN. "Fabrication of Polycaprolactone-Chitosan/Curcumin Polymer Composite Fibers and Evaluation of Their in Vitro Release Kinetic Behavior and Antibacterial-Antifungal Activity". Journal of Sol-Gel Science and Technology, (2023).en_US
dc.identifier.urihttps://hdl.handle.net/11352/4679
dc.description.abstractMicroencapsulation is an attractive method in the production of controlled release and targeted delivery systems and is widely used to increase the bioavailability of antimicrobial molecules. Chitosan (CS) is commonly used as the wall material of microcapsules and demonstrates antibacterial and antifungal features. In this study, curcumin (CUR) and CS as bioactive substances were loaded in polycaprolactone (PCL) by microencapsulation method. The electrospinning method was used for the production of microencapsulated biomaterials as polymer composite fibers. SEM analysis of polymer composites was performed and the fiber size of PCL-CUR/CS composite fiber was measured as 248.71 ± 98 nm. The bioactive release kinetics correlation coefficient (R2 ) value and mathematical model of the polymer compounds were analyzed as PCL-CS/CUR; 0.98, Zero order, PCL-CUR; 0.93, Korsmeyer-Peppas and PCL-CS; 0.95 Higuchi, respectively. Antifungal activity experiments were performed on the obtained polymer composite fibers and the minimum inhibitory concentrations of PCL-CS, PCL-CUR, and PCL-CS/CUR composite fibers against Aspergillus niger were determined as >5000 ppm, 750 ppm, 2500 ppm, and 2500 ppm, respectively. The minimum inhibitory concentrations of PCL-CS, PCL-CUR, and PCL-CS/CUR against Penicillium digitatum were >5000 ppm, 250 ppm, 1666 ppm, and 1666 ppm, respectively. These results revealed that PCL/-CS/CUR polymer composite fibers may be used as both antifungal and antibacterial bioactive material in tissue engineering applications.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s10971-023-06264-xen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.titleFabrication of Polycaprolactone-Chitosan/Curcumin Polymer Composite Fibers and Evaluation of Their in Vitro Release Kinetic Behavior and Antibacterial-Antifungal Activityen_US
dc.typearticleen_US
dc.relation.journalJournal of Sol-Gel Science and Technologyen_US
dc.contributor.departmentFSM Vakıf Üniversitesi, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorÇiftçi, Fatih


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record