| dc.description.abstract | Bacterial cellulose (BC), synthesized by
strains such as Acetobacter xylinum, has gained significant
attention as a highly versatile biomaterial for
the development of nano-biosensors, particularly in
therapeutic technologies. Unlike plant-derived cellulose,
BC is devoid of lignin and hemicellulose,
providing a pure nanofibrous structure with distinct properties, including high crystallinity, mechanical
strength, biocompatibility, and exceptional waterholding
capacity. These characteristics make BC
an ideal platform for biosensor integration, offering
enhanced sensitivity, selectivity, and real-time monitoring
capabilities—key advantages for biomedical
applications. BC-based biosensors present significant
improvements over traditional technologies, particularly
in early-stage disease detection and personalized
medicine. The nanofibrillar structure of BC provides
a large surface area for the immobilization of bio-recognition
elements, such as enzymes, antibodies, and
nucleic acids, facilitating superior signal transduction
and enabling the detection of biomarkers at lower
concentrations. This heightened sensitivity is crucial
for early diagnosis, where conventional methods
often fail to detect subtle biomolecular changes. Furthermore,
BC’s inherent biocompatibility makes it an
ideal material for the development of wearable biosensors
capable of continuous monitoring and delivering
patient-specific data. A prominent application
of BC-based biosensors is in wound healing, where
BC’s high water retention capacity supports an optimal
moist environment for accelerated healing. When
integrated with biosensing elements, BC wound
dressings can monitor critical biomarkers, such as pH
levels or the presence of specific pathogens, allowing
for timely intervention and improved patient outcomes.
BC-based biosensors have also been explored
for use in drug delivery systems, where biosensors
can detect specific biological cues to trigger the controlled release of therapeutic agents at targeted
sites, thus minimizing side effects and enhancing the
efficacy of treatments. In addition to its biomedical
applications, BC is a sustainable and environmentally
friendly material derived from renewable sources. Its
biodegradability and ease of functionalization further
enhance its potential for diverse medical applications.
As a bio-based material, BC contributes to reducing
the environmental impact of medical technologies
while offering high-performance solutions. In summary,
BC-based nano-biosensors represent a transformative
approach to therapeutic technologies, offering
enhanced performance in sensitivity, selectivity,
and real-time monitoring. As research advances, BC’s
integration into medical devices holds great promise
for the future of sustainable, patient-centered healthcare
solutions. | en_US |
