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Virtual Birefringence Imaging and Histological Staining of Amyloid Deposits in Label-Free Tissue Using Autofluorescence Microscopy and Deep Learning
Yang, Xilin; Bai, Bijie; Zhang, Yijie; Aydın, Musa; Li, Yuzhu; Selcuk, Sahan Yoruc; Costa, Paloma Casteleiro; Guo, Zhen; Fishbein, Gregory A.; Atlan, Karine; Wallace, William Dean; Pillar, Nir; Özcan, Aydoğan (Nature, 2024)Systemic amyloidosis involves the deposition of misfolded proteins in organs/ tissues, leading to progressive organ dysfunction and failure. Congo red is the gold-standard chemical stain for visualizing amyloid deposits ...