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dc.contributor.authorÖzarslan, Ali Can
dc.contributor.authorÇiftçi, Fatih
dc.date.accessioned2024-04-30T10:00:16Z
dc.date.available2024-04-30T10:00:16Z
dc.date.issued2023en_US
dc.identifier.citationÖZARSLAN, Ali Can & Fatih ÇİFTÇİ. " A Comparative Study of Release Kinetics Behavior Models and Shelf Life Assessment of Bacitracin Zinc-Loaded Pla Composites". Konya Journal of Engineering Sciences, 11.4 (2023): 1006-1015.en_US
dc.identifier.urihttps://dergipark.org.tr/en/pub/konjes/issue/81121/1328688
dc.identifier.urihttps://hdl.handle.net/11352/4913
dc.description.abstractMathematical modeling aims to simplify the complex process of drug release and to gain knowledge about the release mechanisms specific to a given material system. Consequently, a mathematical model focuses primarily on one or two important factors. Drug release aims to maximize the bioactivity of both naturally derived and synthetically derived macromolecules, thus increasing their clinical applicability and improving the overall quality of life. This study focused on fabricating PLA composites with different weight percentages of Bacitracin Zinc (0.5, 1.0, and 2.0) and evaluating their potential as a drug delivery system. To understand the release mechanism of Bacitracin Zinc from the PLA composites, we developed a Franz diffusion kinetic model and a mathematical model for cumulative release kinetics. The Franz diffusion model was utilized to analyze the release behavior of the PLA/Bacitracin Zinc composite structure. The results indicated a sustained release rate, following a Zero Order release kinetics pattern. Furthermore, the shelf life of the composite structure was determined to be 125 days. Python programming was employed to model the release behavior and estimate the shelf life of Bacitracin Zinc (0.5, 1.0, and 2.0) incorporated into the PLA matrix to compare different weight percentages' behavior and shelf life.en_US
dc.language.isoengen_US
dc.publisherKonya Technical Universityen_US
dc.relation.isversionof10.36306/konjes.1328688en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacitracin Zincen_US
dc.subjectCompositeen_US
dc.subjectPLAen_US
dc.subjectDrug Release Kineticen_US
dc.subjectFranz Diffusion Kinetic Modelen_US
dc.titleA Comparative Study of Release Kinetics Behavior Models and Shelf Life Assessment of Bacitracin Zinc-Loaded Pla Compositesen_US
dc.typearticleen_US
dc.relation.journalKonya Journal of Engineering Sciencesen_US
dc.contributor.departmentFSM Vakıf Üniversitesi, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.contributor.authorIDhttps://orcid.org/0000-0002-4864-0598en_US
dc.contributor.authorIDhttps://orcid.org/0000-0002-3062-2404en_US
dc.identifier.volume11en_US
dc.identifier.issue4en_US
dc.identifier.startpage1006en_US
dc.identifier.endpage1015en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorÇiftçi, Fatih


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