A Dual-Model AI Framework for Alzheimer’s Disease Diagnosis Using Clinical and MRI Data

Abstract

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that requires advanced diagnostic strategies for early and accurate detection. Methods: This study introduces a hybrid AI-driven diagnostic framework that integrates an Artificial Neural Network (ANN) trained on clinical data from 1,200 patients using 31 demographic, symptomatic, and behavioral features with a Convolutional Neural Network (CNN) trained on 4,876 MRI images to classify AD into four stages. Results and Discussion: The ANN achieved an accuracy of 87.08% in earlystage risk prediction, while the CNN demonstrated a superior 97% accuracy in disease staging, supported by Grad-CAM visualizations that improved model interpretability. This dual-model approach effectively combines structured clinical data with imaging-based analysis, addressing the sensitivity and scalability limitations of traditional diagnostic methods and providing a more comprehensive assessment of AD. Conclusion: The integration of ANN and CNN enhances diagnostic precision and supports AI-assisted clinical decision-making, with future work focusing on lightweight CNN architectures and wearable technologies to enable broader accessibility and earlier intervention.